zgogor
ah, yes, i get it. i too have lost many more firewire drives than any other kind (4 to date). knock on wood, i've never lost a scsi drive to date (owned 30+). for data security, i find firewire to be really poor. i too had to go through the whole 'VSL reinstall' when 2 firewire drives died. so now i've got the full VSL installed on 3 seperate firewire drives - 1 attached to my system, 2 as backup.
if by HUGE system, you mean a RAID from hugesystems.com - i own one of their older RAIDs. AFAIK, they are built with ATA drives (maybe SATA - haven't checked in a while) not scsi. and mine (dual media vault 1800) only streams at the same level as a single ATA drive.
personally, i think you'd probably be better served in cost/benefit by going with 3 firewire drives (1 for use, 2 for backup). the odds of all 3 drives failing at once is remote - but they will be much cheaper and perform virtually the same, IME.
that said, if you get a dual HUGE system, just leave the two halves of it as 'separate' drives and you should be good for security (especially if you get one with drives you can swap out - no good if you have to send them the unit if a drive fails because then your data is 'lost' for that period of time, too). no point RAIDing the two sides together because it won't improve performance.
also consider a company called RAID Incorporated (raidinc.com) - i've had very good luck with them with scsi raids. i know they also make a new SATA raid, though i have no idea what the price point is.
or you could get the MacGurus (macgurus.com) to build you a 2-4 drive scsi mini-tower and you could install the data across all four drives (or RAID them) and get the best performance and stability available for EXS. i'd still recommend firewire as backup, understanding that the 'backup' will most likely fail first.

hope that helps and best of luck with it