Good information here. http://kb.pert.geant.net/PERTKB/InterruptCoalescence
"While this scheme lowers interrupt-related system load significantly, it can have adverse effects on timing, and make TCP traffic more bursty or "clumpy"."
That's kind of what was happening to my network audio; it would sort of stutter and then "burst", and timing would be all off. It's weird that at 1 buffer in VE Pro it would play fine. I am guessing because the driver was giving higher priority to those packets, but of course it would freak out ASIO. This was mainly on my master DAW. I just turned it off on the slaves for good measure but could probably turn those back on as it started working with just Interupt Moderation off on the master DAW machine.
Also, forgot to say the issue I was experience didn't seem to be system specific as a newly built X79 system exhibited the exact behavior as previous x58 DAW, each with totally different components. I personally think it is somehow related to a change Steinberg did as at first the x58 machine ran fine for a year or so and then I think somewhere along the several Cubendo updates I gradually started noticing this spiking when running VE Pro. Though maybe it could have been one of the VE Pro updates too since the behavior does change depending on the VE Pro buffer.. Who knows.